Sodium-glucose cotransporter 2 inhibition: towards an indication to treat diabetic kidney disease
نویسندگان
چکیده
منابع مشابه
Sodium glucose cotransporter 2 and the diabetic kidney.
PURPOSE OF REVIEW Reabsorption of glucose in the proximal tubule occurs predominantly via the sodium glucose cotransporter 2 (SGLT2). There has been intense interest in this transporter as a number of SGLT2 inhibitors have entered clinical development. SGLT2 inhibitors act to lower plasma glucose by promoting glycosuria and this review aims to outline the effect on the diabetic kidney of this h...
متن کاملInhibition of Sodium-Glucose Cotransporter 2 with Dapagliflozin in Han: SPRD Rats with Polycystic Kidney Disease.
BACKGROUND/AIMS Dapagliflozin (DAPA) is a selective inhibitor of the sodium-glucose cotransporter 2 (SGLT2) which induces glucosuria and osmotic diuresis. The therapeutic effect of DAPA in progressing stages of polycystic kidney disease (PKD) has not been studied. METHODS We examined the effect of DAPA in the Han: SPRD rat model of PKD. DAPA (10 mg/kg/day) or vehicle (VEH) was administered or...
متن کاملMetabolic response to sodium-glucose cotransporter 2 inhibition in type 2 diabetic patients.
BACKGROUND Sodium-glucose cotransporter 2 (SGLT2) inhibitors lower glycemia by enhancing urinary glucose excretion. The physiologic response to pharmacologically induced acute or chronic glycosuria has not been investigated in human diabetes. METHODS We evaluated 66 patients with type 2 diabetes (62 ± 7 years, BMI = 31.6 ± 4.6 kg/m(2), HbA1c = 55 ± 8 mmol/mol, mean ± SD) at baseline, after a ...
متن کاملRenal Glucose Handling Impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes
RESEARCH DESIGN AND METHODSdGlycosuria was measured before and after a single ipragliflozin dose in 8 nondiabetic subjects and 57 T2DM patients (age 62 6 9 years, fasting glucose 133 6 39 mg/dL, mean 6 SD) with normal renal function (assessed as the estimated glomerular filtration rate) (eGFR1 $90 mL z min –1 z 1.73 m), mild (eGFR2 $60 to ,90), moderate (eGFR3 $30 to ,60), or severe reduction i...
متن کاملSodium-Glucose Cotransporter Inhibition Prevents Oxidative Stress in the Kidney of Diabetic Rats
UNLABELLED The hyperglycemia triggers several chronic diabetic complications mediated by increased oxidative stress that eventually causes diabetic nephropathy. The aim of this study was to examine if the sodium-glucose cotransporter (SGLT2) inhibition prevents the oxidative stress in the kidney of diabetic rats. METHODS The diabetic rat model was established by intraperitoneal injection of s...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2020
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfz237